Free download and read ebooks online Group Sequential Methods With Applications To Clinical Trials by Christopher Jennison, Bruce W. Turnbull full book PDF ePUB Audiobook. Download a free ebooks and kindle audiobook Group Sequential Methods With Applications To Clinical Trials with ISBN id 9780849303166 full page with book summary. Christopher Jennison book PDF ePUB of Group Sequential Methods With Applications To Clinical Trials published by Chapman and Hall/CRC in 1999-09-15. Group Sequential Methods with Applications to Clinical Trials released with category Mathematics with total 416 pages.
📖 Group Sequential Methods With Applications To Clinical Trials by Christopher Jennison download book pdf epub
Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
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“We are all in the gutter, but some of us are looking at the stars.” ― Oscar Wilde
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